Simultaneous Determination of Over-the-Counter Pain Relievers in Commercial Pharmaceutical Products Utilizing Multivariate Curve Resolution-Alternating Least Squares (MCR-ALS) Multivariate Calibration Model
نویسندگان
چکیده
منابع مشابه
Application of multivariate curve resolution alternating least squares (MCR-ALS) to the quantitative analysis of pharmaceutical and agricultural samples.
Application of multivariate curve resolution alternating least squares (MCR-ALS), for the resolution and quantification of different analytes in different type of pharmaceutical and agricultural samples is shown. In particular, MCR-ALS is applied first to the UV spectrophotometric quantitative analysis of mixtures of commercial steroid drugs, and second to the near-infrared (NIR) spectrophotome...
متن کاملQuantitative Determination of Formaldehyde by Spectrophotometry Utilizing Multivariate Curve Resolution Alternating Least Squares
Formaldehyde is a vastly used material in industry. Nowadays, it is proven that formaldehyde is toxic and carcinogenic. Thus providing a reliable method for its quantitative determination is very important. This study proposes a UV-Vis spectrophotometric based method for determination of formaldehyde. The method is based on reaction between the analyte and Fluoral P. Spectral changes during the...
متن کاملIdentification of Reliable Components in Multivariate Curve Resolution-Alternating Least Squares (MCR-ALS): a Data-Driven Approach across Metabolic Processes
There is an increasing need to use multivariate statistical methods for understanding biological functions, identifying the mechanisms of diseases, and exploring biomarkers. In addition to classical analyses such as hierarchical cluster analysis, principal component analysis, and partial least squares discriminant analysis, various multivariate strategies, including independent component analys...
متن کاملSimultaneous spectrophotometric determination of lidocaine and hydrocortisone acetate in pharmaceutical preparations by multivariate calibration methods
The multivariate calibration method, partial least square regression (PLS) was applied for thesimultaneous spectrophotometric determination of Lidocaine (LID) and Hydrocortisone acetate(HCA) in their mixtures. The parameters of chemometric technique were optimized and theproposed method was validated with synthetic samples and applied to analyze these drugs inpharmaceutical products with good a...
متن کاملSimultaneous spectrofluorimetric determination of (acetyl)salicylic acid, codeine and pyridoxine in pharmaceutical preparations using partial least-squares multivariate calibration.
A partial least-squares calibration (PLS) method for the simultaneous spectrofluorimetric determination of salicylic acid (SA), codeine (CO) and pyridoxine (PY) is proposed. The determination of SA, CO, and PY has been carried out in mixtures of up to three components by recording the emission fluorescence spectra between 300 and 500 nm (lambda(exc) = 220 nm). Due to the fact of the strong spec...
متن کاملذخیره در منابع من
با ذخیره ی این منبع در منابع من، دسترسی به آن را برای استفاده های بعدی آسان تر کنید
ژورنال
عنوان ژورنال: Journal of Analytical Methods in Chemistry
سال: 2019
ISSN: 2090-8865,2090-8873
DOI: 10.1155/2019/1863910